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Bergamot lowers cholesterol
100% BERGAMOT JUICE – A SAFE WAY TO LOWER YOUR CHOLESTEROL. Bergamot juice is high in polyphenols, a natural compound best known for its antioxidant effects. Polyphenols can help to protect against cardiovascular disease, bone loss, diabetes, and other degenerative disorders.
It has been shown that bergamot juice contains exceptionally large amounts of several unique polyphenols. And, when you drink the juice, this helps reduce triglycerides and LDL cholesterol, raising protective HDL cholesterol.
Statin medicines are known to cause a variety of negative side effects: anything from headaches and nausea to drug interactions that may be cause further health risks. Statins slow the enzyme that causes cholesterol production and they help clear LDL cholesterol from the bloodstream. Statins also help slow the formation of plaque, which can cause blockage or arteries and reduce blood flow to extremities. When blood flow to the heart is blocked and reduced, the risk of heart disease and heart attack are greatly increased. Research shows that Bergamot juice contains the same cholesterol reducing properties as prescription medicines, making Bergamot juice a good, natural option for cholesterol management.
Bergamot lowers cholesterol, without depleting CoQ10. Reducing cholesterol is only possible by blocking an enzyme involved in cholesterol production in the liver and in the synthesis of coenzyme Q10 (CoQ10) a crucial antioxidant. Two polyphenols abundant in Bergamot, bruteridine and melitidine, also target this same pathway, without the side effects of statin medications, so CoQ10 synthesis is not affected.
Lipid levels are just one aspect of cardiovascular health. Bergamot polyphenols are also very potent antioxidants that protect against free radical damage in tissues throughout the body, including the all-important vascular endothelium.
The condition and function of the endothelium – the thin layer of cells lining the blood vessels is perhaps the most important determinant of cardiovascular health, as it is intimately involved in vasoconstriction/dilation and thus blood pressure, inflammation, blood clotting and the formation of new blood vessels. Polyphenol-rich Bergamot extract has been demonstrated to suppress inflammation, inhibit plaque formation and improve arterial responsiveness.
It’s not just people with high cholesterol who may benefit from bergamot. People at risk of diabetes, such as those with pre-diabetes and metabolic syndrome, may benefit as Bergamot has been shown to lower blood glucose levels by between 15-25%. Bergamot juice has shown to initiate the AMP-activated protein kinase (AMPK). AMPK is a central regulator of energy and is involved in glucose and fatty acid metabolism. By activating AMPK, it improves insulin sensitivity, promotes glucose uptake in cells and suppresses the synthesis of glucose in the liver, thus lowering blood sugar levels. In addition, it stimulates the burning of fatty acids and this may, in turn, help with weight control.
Lipid levels are just one aspect of cardiovascular health. Bergamot polyphenols are also potent antioxidants that protect against free radical damage in tissues throughout the body, including the lining of the blood vessels. Our blood vessels are involved in vasoconstriction and dilation – and thus blood pressure, inflammation, blood clotting and the formation of new blood vessels. Because Bergamot juice is rich in polyphenols, it can help to suppress inflammation, inhibit plaque formation and improve arterial health.
Due to Bergamot's lipid-lowering effects, it helps reduce triglyceride accumulation in the liver, a problem common in obese people. It also binds cholesterol to bile acids, which increases its excretion in the intestinal tract.
Before we answer all the most common questions, we need to emphasise that it does take a little time before you start to see results – so you need to be patient and persevere, as you shouldn’t expect an overnight miracle! You need to allow 3 or 4 months of regular, daily consumption of 100mL of our Bergamot Juice before there are noticeable changes and benefits.
How does Bergamot work, and what specific areas does it address?
Bergamot reduces the amount of lipid (cholesterol and triglycerides) consumed through meals. In addition, it reduces the internal formation of cholesterol. Finally, Bergamot helps glucose entry into the cells, thereby producing benefits in patients suffering from metabolic syndrome and diabetes.
How many patients have taken part in clinical trials to date?
In many countries (Italy, Australia and USA) more than 20.000 patients are currently taking Bergamot.
Have there been any side effects for patients taking Bergamot?
To date, we have not significant side effects have been reported.
Can patients take Bergamot while on statins and blood pressure medication?
Many of patients taking Bergamot, are also taking statins or drugs acting on cardiovascular system. No significant changes in their therapeutic response have been found to date.
Can patients who have had heart bypass and stent procedures take Bergamot?
Many patients studied in clinical trials published in specialised journals include those undergoing coronary bypass or stent procedures – Bergamot shows beneficial effects on blood cholesterol and triglycerides.
Why is it important to take Bergamot before meals?
Bergamot has to be taken before meals, since it reduces lipid absorption in the gut.
How does Bergamot compare to other natural products, such as red yeast rice, policosanol and others?
Bergamot is the only natural compound that works simultaneously on cholesterol, triglycerides and blood glucose. It can be taken together with other natural compounds because of a peculiar mechanism within its action.
What qualities does Bergamot possess that other citrus fruits don’t?
Bergamot contains extremely large amounts of polyphenols, as compared to other citrus species. Two of these – Brutelidin and Melitidin –directly inhibit cholesterol biosynthesis in a way similar to statins, and they are not found in any other citrus derivatives.
Does Bergamot have any effect on neuroprotection?
Experimental studies have recently revealed that bergamot extract may have a protective effect on brain tissues.
Does Bergamot have any anti-inflammatory qualities?
Recent studies have also shown that antioxidant molecules contained within Bergamot may produce relevant effects on chronic inflammatory disorders and enhance the effect of drugs, such as morphine acting on pain sensitivity.
Can people stop taking statins immediately, after starting to take Bergamot?
If you are on a statin, you should never stop this without your doctor’s permission and supervision.
If you have been taking statins for any length of time, sudden cessation may lead to a marked rise in cholesterol over the initial levels. This is because statins block the last step in cholesterol production and when these are stopped, there is often an over-reaction of the blocked enzyme system lasting for a 6-8 week period. A natural product, such as Bergamot, is not strong enough to overcome this effect initially, and would not be expected to reduce cholesterol for at least 2-3 months under these circumstances.
Can people take Bergamot whilst also taking Warfarin?
From the studies to date, there is no known interaction between Warfarin and Bergamot.
How does Bergamot differ from grapefruit, and does it have some of the side effects that people experience with grapefruit?
Bergamot has some similar antioxidants to grapefruit– however, grapefruit has a profound effect on the metabolic pathways within the liver, thus blocking many drugs, whereas Bergamot does not appear to have the same effect and therefore appears safe to take with all medications.
Why is it important to take Bergamot prior to meals? Also, is it still a benefit to take after meals, if you forget to take it prior, to eating?
Bergamot has three main modes of action. Firstly, it works to block the rate limiting step in cholesterol production known as the HMG CoA Reductase Enzyme, which is the enzyme that is blocked by statin drugs. Bergamot works at a different site on this enzyme, and therefore does not appear to affect the muscles and the liver in the same way that statin drugs may do. It does, however, have a significant reduction in cholesterol through this first mode of action. Secondly, Bergamot works directly on the insulin receptor, thus affecting the metabolic syndrome, i.e., the combination of the tendency to diabetes, high blood pressure, specific cholesterol abnormalities and abdominal obesity. All of these factors contribute to cardiovascular disease. Thirdly, Bergamot blocks cholesterol absorption in the gut similar to the plant sterols found in some types of margarine and avocado. This is the major reason why it is important to take Bergamot before meals, i.e. to block the absorption of cholesterol and other fats following the ingestion of a meal. Bergamot will still have an action – though not as strong – asif it is taken after meals, but certainly if you forget to take it before, you should still take Bergamot later.
Does it help to lower cholesterol after it has passed through the liver?
It does, but not as much, as it mainly works in the liver and that is precisely how it acts on affecting the cholesterol pathways in the liver. It also has some peripheral metabolic effects but they are not as profound as within the liver.
How does Bergamot help lower blood glucose?
It has an effect on blood glucose because of the direct effect on the “energy receptor” on the cell surface. Apart from the brain, for glucose to enter the cells – and, in particular, the muscles – it has to enter via a receptor which I term the “energy receptor”. Insulin is the doorman that opens the door, to facilitate the entry of glucose and other nutrients into the cells. In people with metabolic syndrome characterised by a tendency to diabetes, hypertension, dyslipidaemia, abdominal obesity and cardiovascular disease, the energy receptor is partially jammed and the only way the body can respond to this is by making more insulin to enter into the cell. Bergamot acts directly on this receptor to facilitate it opening, and thus allow more sugar to enter the cell. This is probably why it also helps to reduce blood pressure and increase HDL.
How does Bergamot help weight loss?
Bergamot activates AMPK which is the metabolic trigger for the breakdown of fat and sugar in the body. AMPK is considered to be a key therapeutic target for the treatment of obesity, Type II diabetics and metabolic syndrome.
When should I examine the results from Bergamot?
Waiting approx 3-4 months appears to be ideal for testing – especially after weight appears to be stable. During active weight loss, cholesterol levels often temporarily rise and give the impression of no improvements.